Five people died and others were injured in southeast Missouri early Wednesday after at least one tornado and other storms moved through the area, officials said. Sheriff Casey Graham of Bollinger County confirmed the deaths in a Facebook post on Wednesday and said that search-and- Rescue operations were still underway. Sheriff Graham said that the Grassy and Glenallen communities, about 120 miles south of St. Louis, “were hit with what appears to be a significant tornado early this morning.” Sgt. Clark Parrott, a public information officer for the Missouri State Highway Patrol, said earlier on Wednesday that damage was widespread and crews were still working to assess the impact at the scene. “There are just multiple homes damaged, missing roofs, power lines, power poles, trees down across multiple highways , making it difficult for first responders,” he said. “This is still a very active search-and-rescue operation.” Gov. Mike Parson of Missouri said on Twitter that he would join emergency workers on the ground to assess the damage. Justin Gibbs, a meteorologist with the Weather Service in Paducah, Ky., said early Wednesday that there had been at least one tornado overnight in Bollinger County, in southeast Missouri. Mr. Gibbs said that there was “quite a bit of damage” and that radar suggested a “potentially pretty strong tornado.” Joshua Wells, 30, who lives in Glenallen in central Bollinger County, said there was extensive damage in the area, including uprooted trees, homes with roof damage and an auto repair shop that had been “twisted.” “A lot of older structures have been completely leveled,” Mr. Wells said. Having experienced a tornado before, Mr. Wells said he was awake before the tornado moved through and had gone next door to his sister’s house to shelter “I’m always wary of bad weather,” Mr. Wells said. “I had that gut feeling that we should definitely take shelter.” The bad weather was expected to continue well into the day, potentially bringing severe storms to a broad region of the central United States that stretches from Memphis to southern Michigan, the National Weather Service said in a forecast. More than 10 million people in portions of Indiana, Michigan and Ohio were under a tornado watch, in effect until 4 pm, meaning that Conditions in and around the region were favorable for tornadoes and severe thunderstorms. By 11 am Central time, more than 110 flights had been canceled and more than 200 others were delayed out of Chicago O’Hare International Airport, according to FlightAware, a flight tracking company. Dozens more cancellations and delays were also reported at Chicago Midway International Airport and St. Louis Lambert International Airport. And in the Upper Plains and Rockies, heavy snow was falling and several major roads were closed early Wednesday, as drivers faced poor visibility and other hazards. More than a million people were under blizzard warnings, and the Weather Service said that several inches were likely to fall in parts of North Dakota and Minnesota by the evening. The central United States has had a run of bad weather recently, including destructive tornadoes and blizzards that hammered the region last week. On Tuesday, several fresh tornadoes were reported in Iowa, Missouri and Illinois. In Colona, Ill., about 80 miles southeast of Cedar Rapids, Iowa, a tornado ripped the roof from a gas station and uprooted trees, according to the service. The local police said that two people had been evacuated safely from the station, and that no injuries were reported. In Iowa, the storms rumbled near areas where tornadoes had torn roofs off homes and other buildings days earlier, displacing residents. One of those residents, Jacob Dilks of Hills, Iowa, said he had been on an “emotional roller coaster” ever since his home was destroyed last Friday. On Saturday, his son turned 2. On Tuesday, his wife gave birth to a girl. “One minute, you’re scared for the lives of your family, and the next you’re happy to be alive,” said Mr. Dilks, 28, whose family has been staying with relatives in nearby Coralville. Destructive, baseball-size hail was also reported on Tuesday afternoon in towns in northeast Illinois. The roughly three-inch hail that fell in the Chicago area was the largest since a July 2020 storm, according to the National Weather Service in Chicago. The Chicago Fire Department said that high winds had downed trees and power lines, and damaged buildings. In Chicago, where voters on Tuesday elected Brandon Johnson as mayor, people appeared to heed a call to vote early, ahead of bad weather, according to Max Bever, a spokesperson for the Chicago Board of Elections. As of noon local time, the number of ballots cast reflected a 23 percent citywide turnout, compared with 21 percent at noon in the previous election on Feb. 28. Aside from a dip in voter turnout in the early afternoon as a thunderstorm rolled through, the elections board was not aware of other storm-related effects on turnout, Mr. Bever said on Tuesday night. He added that the overall turnout figure for the day was relatively low for an election day. Much of the tornado risk early Wednesday was concentrated over Arkansas, where five people died in separate tornadoes last Friday. Forecasters said on Tuesday night that they were monitoring a potential tornado threat over an area including Little Rock, the capital. Scientists yet able to determine whether there is a link between climate change and the frequency or strength of tornadoes. Researchers do say that in recent years tornadoes seem to be occurring in greater clusters, and that the region known as tornado alley in the Great Plains, where most tornadoes occur, appears to be shifting eastward. Cindy Hadish, Johnny Diaz and Jesus Jiménez contributed reporting.